We have developed novel and innovative techniques to deliver compounds to the CNS and enhance in vivo imaging capabilities.
By using advanced nanoparticles and silica we can enhance drug solubility, target delivery of compounds to where they need to go, and advance current visualisation limitations.
Zebrafish offer some unique advantages to advance such delivery systems as they are transparent when they are young, and we can track such imaging options and delivery systems under the microscope.
ZEBRAFISH NANOPARTICLE INJECTIONS
To assess the efficiency of a new nanoparticle formulation we visualised these CaP-lipid particles after tail vein injection in transgenic zebrafish.
UPCONVERSION NANOPARTICLES IN THE CNS
We used a novel type of upconversion nanoparticles (UCNPs) to evaluate their uptake and sensitivity in neuronal cell lines and zebrafish.
A NEW IMAGING MODALITY USED IN GLIOBLASTOMA
Development of new high-resolution nanoparticles to target apolipoprotein E to GBM tumours.